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Adderall & Vitamin C interaction

June 21st, 2009

I am working with a new psychiatrist (nothing wrong with the old one; Dr. W specializes in mid-life women with ADHD). She is running me through a trial of three new meds, none of which were on the market 15 years ago when I first tried on ADD meds  – gosh has it been that long ago?

It was a complete surprise to me to learn that stimulant medications have a distinct and negative interaction with foods that contain Vitamin C. Apparently the Vitamin C diminishes the effectiveness of the medication.*

Huh? I had NO idea this was true. I don’t know about you, but I want all the bang for my medication buck possible, so I’m gonna follow her suggestions (which she found on the package inserts of Adderall XR and Dexadrine Spansules – I need to get out my reading glasses to check that teeny tiny print more carefully).

Here’s the rule:

No foods with Vitamin C one hour before or after taking stimulants

Vitamin C big players on the food court include:

Oranges – juice or fruit
Grapefruit – juice or fruit
Strawberries
Papaya
Kiwi fruit
Mango
Cantaloupe
Lemons/lemonade
Limes/limeade

Potatoes (this is not a misprint)
Brussels sprouts
Broccoli
Kale
Cauliflower (who knew?)
Parsley
Mustard greens
Bell peppers
 

Other sneaky sources of Vitamin C

Coke/soft drinks/colas (!!!!)
Power bars
Fortified cereal
Power drinks
Granola bars
Pop Tarts
Any kind of jam or jelly made from fruits listed above

And of course…
Vitamins – multi-vitamins
Vitamin C tablets

 FYI
Dr. Wojdyska also nixes taking antibiotics in that two hour time span. And I found on the Adderall XR site that melatonin reacts with the medication, too. Insomniacs beware .. but only for that short time period.

(If you think taking an antacid like TUMS will allow you to eat citrus, you’re right, but note that *taking antacids INCREASES the effect of Adderall. Be careful out there….)

Thanks, Dr. W – you’re the best.

And now you know the rest of the label…

Hugs

Linda

*From the FDA site re: interactions with Adderall XR
Drug Interactions:
Acidifying agents -Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCl, ascorbic acid, etc.) lower absorption of amphetamines.
Urinary acidifying agents -These agents (ammonium chloride, sodium acid phosphate, etc.) increase the concentration of the ionized species of the  amphetamine molecule, thereby increasing urinary excretion. Both groups of agents lower blood levels and efficacy of amphetamines.
Alkalinizing agents -Gastrointestinal alkalinizing agents (sodium bicarbonate, etc.) increase absorption of amphetamines. Co-administration of ADDERALL XR® and gastrointestinal alkalinizing agents, such as antacids, should be avoided. Urinary alkalinizing agents (acetazolamide, some thiazides) increase the concentration of the non-ionized species of the amphetamine molecule, thereby decreasing urinary excretion. Both groups of agents increase blood levels and therefore potentiate the actions of amphetamines.




 

 

Keeping ADHD meds in perspective

March 19th, 2008

Ever get "The Look" when you casually mention ADD or ADHD to a friend or colleague? It’s that poor-you-for-buying-into-the-hype cover-up smile that implies you are sadly mistaken about the validity of ADHD.

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Wellbutrin generic – bad news?

November 4th, 2007

I’ve always worried that generic drugs aren’t quite as good as the brand name version and now there’s mounting evidence to prove it.

Wellbutrin XL 300 (Budeprion XL) works just fine for depression and many ADHD symptoms. But when some patients are switched to the generic formulation, they reported frightening symptoms: fast onset of severe depression and serious suicidal thoughts.

In a recent article published by the People’s Pharmacy a woman reported no problems with the original Wellbutrin XL 300 but said that she had "the worst case of depression" she could remember when her pharmacy substituted the generic equivalent. It should be noted that the difference has not been reported in the 150 XL formulation at this point.

Apparently the generic version releases the medication at a different rate than the original, thus creating quite different response rates and effectiveness.

This news scares me – because a lot of ADDivas take Wellbutrin, including me – and there is the potential for serious repercussions. Suicide is not to be taken lightly, especially when antidepressants are supposed to ward off those thoughts and actions.

Equally important, however, is that many ADD women and men have already experienced differences in generic medications vs. brand name drugs that treat ADHD. I cannot take generic Adderall, for instance. Other people cannot take the brand name version. Ditto for any of the other drugs on the market today.

There are two ways to look at this issue, in my opinion.

1) We need to make SURE that we are receiving the exact drugs prescribed for us with NO substitutions by the pharmacy or insurance company (this may take some lobbying by you or your doctor).

2) If generics really do release their active ingredients at different rates than the original drug, it gives us even MORE options to play with to treat our ADHD symptoms.

After all, drug companies are making a fortune by adjusting the release time of ordinary drugs like old fashioned Ritalin, slapping their brand on the bottle and charging 10 times the price of generics. I know folks who can’t take the brand name drug but have good results with the generic. It works both ways. But the bottom line is the same: we all react differently to medication release schedules, to the type of drug prescribed, to the interval we take the drug, etc.

OK, now the disclaimer: this is NOT something to play with on your own. Obviously there can be serious consequences. Drugs are not a smorgasbord from which we can pick and choose. Work with your doctor to find the best combination for you.

But if you are switched to a generic and suddenly notice your symptoms change, call the pharmacy AND the doctor immediately. You deserve to take the meds that work best for you,
brand name OR generic.

Read the full report at Consumer Lab.

Neurons, anyone?

June 6th, 2005

It’s 6:15 am in California and I’m sitting at the pumpkin-colored Formica breakfast bar that separates the living room from the kitchen in my tiny retreat cottage. The cottage is actually a one-bedroom trailer anchored into the rocky north San Diego County hills.

I booked it to accommodate my return appointment at the Hallowell West Clinic. I am determined, at last, to stand toe-to-toe with my Attention Deficit Disorder.

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